DETAILS, FICTION AND TRACLEER

Ketoconazole Coadministration of bosentan 125 mg two times each day and ketoconazole, a strong CYP3A inhibitor, elevated the plasma concentrations of bosentan by close to 100% in normal volunteers. No dose adjustment of bosentan is necessary, but improved effects of bosentan really should be deemed.Most of the pathways governing the changeover of f